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Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats: Carina Vingsbo-Lundberg , Niklas Nordquist, Peter Olofsson, Mats Sundvall, Tore Saxne, Ulf Pettersson and Rikard Holmdahl.
Nat Genet. 1998 Dec;20(4):401-4
Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Olofsson P, Holmberg J, Tordsson J, Lu S, Akerstrom B, Holmdahl R.
Nat Genet. 2003 Jan;33(1):25-32.
Identification and isolation of dominant susceptibility loci for pristane-induced arthritis. Olofsson P, Holmberg J, Pettersson U, Holmdahl R. J Immunol. 2003 Jul 1;171(1):407-16.
Positional cloning of Ncf1-a piece in the puzzle of arthritis genetics. Olofsson P, Holmdahl R. Scand J Immunol. 2003 Aug;58(2):155-64.
Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Hultqvist M, Olofsson P, Holmberg J, Backstrom BT, Tordsson J, Holmdahl R. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12646-51
T cell surface thiol levels set the threshold for auto-reactivity and are determined by Ncf1 expressing cells in the thymus. Kyra.A. Gelderman, Malin Hultqvist, Jens Holmberg, Peter Olofsson and Rikard Holmdahl. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12831-6.
A new therapy of arthritis in rats using oxidative burst inducers. Malin Hultqvist, Peter Olofsson, Kyra Gelderman, Jens Holmberg, Shemin Lu and Rikard Holmdahl. PLoS Med. 2006 Sep 12;3(9). Arthritis suppression by NADPH activation operates through an interferon-beta pathway. Olofsson P, Nerstedt A, Hultqvist M, Nilsson EC, Andersson S, Bergelin A, Holmdahl R. BMC Biol. 2007 May 9;5:19.
Rheumatoid Arthritis: The Role of Reactive Oxygen Species in Disease Development and Therapeutic Strategies.Gelderman KA, Hultqvist M, Olsson LM, Bauer K, Pizzolla A, Olofsson P, Holmdahl R. Antioxid Redox Signal. 2007 Aug 3;
Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species. Gelderman KA, Hultqvist M, Pizzolla A, Zhao M, Nandakumar KS, Mattsson R, Holmdahl R. J Clin Invest. 2007 Oct;117(10):3020-8.
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