Psoriasis (Ps) is a chronic inflammatory skin disease with systemic manifestations dependent on both genetic and environmental factors. Ps is characterized by a thickening of the epedermis and immune infiltrates throughout the dermis and epidermis, causing skin lesion that affect quality of life. Many patients affected by psoriasis also develop inflammation in other organs, often joints as in psoriatic arthritis (PsA). To study the disease pathogenesis, animal models are a good tool.