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Rat models of MS

EAE resembles the human disease in many ways. However, based on the heterogeneity of disease course and lesion pathology in MS it is difficult to model all aspects of MS in one animal model. Thus, the availability of different rat strains, immunogens and adjuvants is very valuable since it allows inducing different types of disease and pathologies. In addition to the actively induced models, the CD4+ T cell dependency of the rat EAE models allows for adoptive T cell transfer of autoimmune T cells after ex vivo re-stimulation.


Rat models of MS


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Rat EAE models Mouse EAE models
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