Acute LPS induced inflammation (Sepsis)

Administration of the endotoxin Lipopolysaccharide (LPS) to mice induce acute inflammatory responses similar to the inflammatory respose that occures during the early stages of septic shock. Shortly after administration of endotoxin, cytokines and chemokines including TNF-a and IL-6 are released. The model is short and thus a cost-effective assay for screening of anti-inflammatory properites of test items aimed for treatment of inflammatory and autoimmune conditions. 

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LPS induced acute inflammation in mice

LPS is administered intraperitoneally to mice and two hours following induction of the inflammatory response, blood is taken for analyisis of cytokines and inflammatory markers using ELISA, flow cytometry, Luminex. 

Test items can be administred before or after induction of inflammation.