Systemic Lupus Erythematosus is a highly complex and heterogenous autoimmune disease more often affecting women in their child-bearing years. The disease is characterized by circulating autoantibodies to nuclear antigens (ANAs) such as anti-Sm and anti-dsDNA, immune complex formation and inflammation in multiple organs. The inflammatory response can lead to tissue damage. Animal models for SLE composes of both induced, spontaneous and genetically modified models. These models, to varying degrees, mimic the hallmarks of the human disease and are good tools for evaluation of efficacy of novel therapies.
- NZB/W F1
- C57Bl.6 with a functional mutation in Ncf1