There are several mouse models for SLE, mimicing different aspects of the disease to varying extent and partial lupus-like syndromes may provide important insights into the pathogenesis of the individual manifestations of SLE. These models, to varying degrees, mimic the hallmarks of the human disease and are good tools for evaluation of efficacy of novel therapies. Among the most studied spontaneous model strains are the NZB/W F1 and MRL/Lpr strains. The spontaneous models have the advantage that genetic susceptibility factors are important as in human SLE while the pristane induced models have the IFN type I signature.