Collagen antibody induced arthritis (CAIA) in mice is an arthritis model independent of both B and T cells. Disease is induced with antibodies to collagen type II. The antibodies bind to cartilage, thereby activating the immune system and recruiting macrophages and granulocytes to the joints. CAIA is an acute model of arthritis. CAIA can also be used to investigate timing of the effect of a potential therapy by administrating the drug at different days after disease induction. CAIA in the susceptible strains DBA/1 or BALB/c has a disease course that is highly predictable with an onset after LPS boost day 5. The disease reaches maximum severity around day 15 and is thereafter healing out.