Mice with the 6-OHDA lesions are widely used as reliable model for understanding of the mechanisms underlying parkinsonian symptoms, since it recapitulates the changes in basal ganglia circuitry and pharmacology observed in parkinsonian patients. Moreover, the 6-OHDA lesion-model is a great tool to study the effects of symptomatic, neurorestorative, or neuroprotective treatments for Parkinson's disease.
Chronic treatment of 6-OHDA-lesioned mice with the neuroprotective drug PRE-084 induces motor recovery. The 2 different behavioral tests were assessed once a week in mice treated with either PRE-084 (0.3mg/kg) or saline solution. Sham animals are naïve, non-treated animals. Results are expressed as number of spontaneous ipsilateral rotations during a 10 min test session (A), or as a percentage of supporting wall contacts (B) performed with the paw contralateral to the lesion (left paw).