Innovative Medicines Initiative BTCure, in which Redoxis is a partner, has combined experience from laboratories worldwide to establish standardised protocols for animal models of Rheumatoid Arthritis. Recently, a paper describing the Pristane Induced Arthritis (PIA) model was published in PLOS ONE.

PIA in rats is a highly reproducible models suggest to reflect the early events of RA and are involving MHCII restricted self-reactive T cells. This chronic relapsing model is one of few that fulfils the American College of Rheumatology (ACR) classification criteria for RA.

Please download the open access article here and contact us for further information on the model and a quote.